Keywords:CARDIOVASCULAR DISEASE, HYPERCHOLESTEROLEMIA - Plant Stanol Esters, Plant Stanols, Mediterranean Diet
Reference:“Effect of a plant stanol ester-containing spread, placebo spread, or Mediterranean diet on estimated cardiovascular risk and lipid, inflammatory and haemostatic factors,” Athyros VG, Kakafika AI, et al, Nutr Metab Cardiovasc Dis, 2009 Nov 23; [Epub ahead of print]. (Address: Atherosclerosis and Metabolic Syndrome Units, 2nd Propedeutic Department of Internal Medicine, Aristotelian University, Hippocration Hospital, 49 Konstantinoupoleos St, Thessaloniki 546 42, Greece).
Summary:In a randomized, placebo-controlled, prospective study involving 150 mildly hypercholesterolemic subjects randomized to a Mediterranean diet, a spread containing plant stanol esters (2 g/d), or a placebo, consumption of a plant stanol ester spread was found to significantly reduce total cholesterol (-14%), LDL cholesterol (-16%), hsCRP (-17%), and estimated CVD risk (26-30%), after 1 month of supplementation, while adherence to a Mediterranean diet also brought about equally beneficial effects, gradually over the course of 4 months, with estimated CVD risk reduced by 24-32%. These results suggest that mildly hypercholestetolemic subjects may reduce their risk of CVD through supplementation with plant stanol esters or adhering to a Mediterranean diet.
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