Elevated Plasma Homocysteine Linked to Advanced Arterial Stiffness
Keywords:ARTERIAL STIFFNESS, CARDIOVASCULAR DISEASE, ATHEROSCLEROSIS, INFLAMMATION - Homocysteine
Reference:“Associations of plasma homocysteine level with brachial-ankle pulse wave velocity, LDL atherogenicity, and inflammation profile in healthy men,” Yun J, Kim JY, et al, Nutr Metab Cardiovasc Dis, 2009 Oct 22; [Epub ahead of print]. (Address: National Research Laboratory of Clinical Nutrigenetics/Nutrigenomics, Dept. of Food and Nutrition, College of Human Ecology, Yonsei Univ., Seoul, Republic of Korea).
Summary:In a cross-sectional study involving 612 healthy men between the ages of 31 and 79 years, higher total homocysteine (tHcy) concentration was found to be associated with increased arterial stiffness (assessed via brachial-ankle pulse wave velocity), increased inflammation (assessed via interleukin-1beta, TNF-alpha), increased oxidized LDL, decreased folate and decreased vitamin B12. In a subgroup of subjects with elevated tHcy, tHcy was also positively associated with blood pressure and negatively associated with LDL particle size. The authors conclude, “This study shows an association between high levels of plasma tHcy and more advanced arterial stiffness, smaller LDL particle size, and higher levels of oxLDL and cytokines in men with hyperhomocysteinemia. Enhanced arterial stiffness in hyperhomocysteinemia might be attributed, in part, to Hcy-related LDL atherogenicity.”
Dr. Rick Rosa
Temple Hills, MD
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