Keywords:PROSTATE CANCER, MORTALITY - Vitamin B6, B Vitamins, Folate, One-Carbon Metabolism Nutrients
Reference:“One-carbon metabolism-related nutrients and prostate cancer survival,” Kasperzyk JL, Fall K, et al, Am J Clin Nutr, 2009; 90(3): 561-9. (Address: Harvard School of Public Health, Department of Epidemiology, Boston, MA 02115, USA. E-mail: julie.kasperzyk@channing.harvard.edu ).
Summary:In a population-based, prospective study involving 525 men diagnosed with prostate cancer between 1989 and 1994, who were followed up with for a median 6.4 years, dietary intake of vitamin B6 was found to be inversely associated with prostate cancer-specific death (HR=0.71), particularly in men with a diagnosis of localized-stage disease (HR=0.71), but not advanced-state disease (HR=1.04), when comparing subjects in the highest versus the lowest quartiles of vitamin B6 intake. No significant associations were found between intakes of folate, riboflavin, vitamin B12, and methionine and prostate cancer survival. The authors conclude, “A high vitamin B-6 intake may improve prostate cancer survival among men with a diagnosis of localized-stage disease.”
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